Beilstein J. Nanotechnol.2017,8, 1637–1641, doi:10.3762/bjnano.8.163
inflammatory and immunological processes. Furthermore, our results on particle-based NO sensing and previous studies in targeting intestinalinflammation via (PLGA)-based microspheres demonstrate that an advanced concept for visualizing intestinalinflammation is tangible.
Keywords: functional imaging
; intestinalinflammation; microparticle; molecular imaging; nitric oxide; Introduction
Inflammation and malignancies are fundamental aspects of many human diseases. Nitric oxide (NO) has been proposed to be an important mediator of inflammation and carcinogenesis. Chronic inflammation, as found in
approach is based on the epithelial barrier dysfunction of the intestine during intestinalinflammation. The intestinal barrier shows an increased permeability by disabled tight junction proteins, alterations in the thickness and composition of the mucus. Thus, particles penetrate and accumulate only into
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Figure 1:
Scanning electron microscopic images of blank (A) and NO550-loaded (B) polymeric microspheres.